「Super-Parallel MR Microscope 」

Abstract

  A super-parallel Mr microscope in which multiple (up to 100) samples can be imaged simultaneously at high spatial resolusion is described. The system consisys of a multichannel transmitter-receiver system and a gradient probe array housed in a large-bore magnet. An eight-channel MR microscope was constructed for verification of the system concept, and a four-channel MR microscope was constructed for a practical application. Eight chemically fixed mouse fetuses were simuitaneously imaged at the 200 μm³ voxel resolution in a 1.5 T superconducting magnet of a whole-body MRI, and four chemically fixed human embryos were simultaneously imaged at 120 μm³voxel resolution in a 2.35T superconducting magnet. Although the spatial resolutions achieved were not strictly those of MR microscopy, the system design proposed here can be used to attain a much higher spatial resolution imaging of multiple samples, because higher magnetic field gradients can be generated at multiple positions in a homogeneous magnetic field.